依达拉奉是一种作用机制明确的新型自由基清除剂,目前主要用于脑梗死的治疗.近年来的临床和动物实验已证实依达拉奉可以作用于多个器官,缺血/再灌注期间,依达拉奉可通过加快羟自由基的清除,下调炎症过程,降低基质金属酶的水平,抑制一氧化氮的过度生成,减缓凋亡细胞和坏死细胞的死亡过程,对心肌、肺、肠、肝脏、胰腺和肾脏等器官产生较好的保护作用,提示围术期早期使用依达拉奉,对上述器官功能损伤具有较好的干预治疗作用,可明显改善患者预后.%Oxaliplatin in combination with other anti-neoplastic drugs can enhance the curative effect and reduce the side effects induced by excessive doses. Molecularly targeted agents are also successively used in antineoplaitic therapy,which has great significance for individual therapy. Here is to make a review on the research progress of a new generation of anticancer drug oxaliplatin from the perspectives of pharmacokinetics characteristies, mechanism oi action, mechanism oi resistance, adverse reactions and clinical application etc. ,to provide a certain reference for the individualized oxaliplatin dosage;and elaborate the drug resistance mechanism from the perspective oi cell cycles, and make a summary oi the conventional dm g-resistance mechanism theories.
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