单磷酸腺苷激活蛋白激酶的活性调节

摘要

AMP-activated protein kinase( AMPK)has emerged as a key molecular player in energy ho-meostasis at both cellular and body level. AMPK activated by various means stimulates catabolic pathways ( fatty acid oxidation,mitochondrial biogenesis and glyolysis )and inhibits anabolic pathways( glycogen,gluco-neogenesis,protein and fatty acid synthesis ). It has a direct appetite-regulating effect in the hypothalamus, called "energy switch". Here is to make a review on the researches about the effect of the regulation of AMPK activity.%AMP激活蛋白激酶(AMPK)是参与细胞及全身水平能量代谢调节的一个关键分子,AMPK通过各种途径激活后可以刺激分解代谢途径(脂肪酸氧化、线粒体的生物合成和糖酵解)和抑制合成代谢途径(糖原、葡萄糖、蛋白质及脂肪酸的合成),并具有直接调节下丘脑对食欲的影响,被称为"能量开关".现就AMPK活性调节机制的研究进展进行综述.