激肽释放酶结合蛋白KBP在炎症中的作用机制及研究进展

摘要

Plasmakinin,the terminal effective substance of Kallikrein-kinin system,exsists in many tis-sues and organs,and regulats a variety of biological functions.Kallikrein-binding protein(KBP) is previously identified as a kind of special inhibitor of kallikrein ,which inhibits the biological response via preventing the release of plasmakinin.Suppressing inflammation is one of the most important effects of KBP.It inhibits the inflammatory response by preventing the release of plasmakinin,promoting the expression of SOCS3 of macro-phage,and suppressing the oxidative stress,and ultimately,it regulates the level of cytokine and thus suppres-ses inflammation effectively.%激肽是激肽释放酶－激肽系统的终末效应物质，并且存在于许多组织器官中，参与各种生物学功能的调控。研究发现组织激肽酶结合蛋白（KBP）是一种激肽释放酶的特殊抑制因子，它可以通过抑制激肽释放在一定程度上发挥生物学作用。 KBP抑制炎症作用是其重要作用之一。 KBP通过抑制激肽释放酶－激肽系统、促进巨噬细胞细胞因子信号抑制子3的表达、抑制氧化应激等途径，最终调控炎症因子的水平，从而有效抑制炎症。