酒精使用障碍患者戒断后磁共振波谱变化和相关机制的研究进展

摘要

Magnetic resonance spectroscopy(MRS) is the only method of in vivo detection of neurometabolites that can detect changes in neurometabolites after severe and light drinking withdrawal.Changes in genetic material after withdrawal is one of the possible mechanisms of the dynamic changes of MRS.Observing the changes of inflammatory cytokines in the blood after withdrawal may indirectly reflect the changes of inflammatory factors in the brain,which can also better explain changes in MRS.In the future we can use the combination of modern genetics methods,blood inflammatory cytokines and MRS,to more accurately determine the dynamic neurometabolites level changes after withdrawal of patients with alcohol abuse,which can also play a predictive role in the patients after withdrawal and health population without physical symptoms and brain structure changes,and provide a reference for further understanding of the biological mechanism of alcohol addic-tion.%磁共振波谱是目前已知的唯一神经代谢物在体检测方法,该方法可检测到重度饮酒和轻度饮酒戒断后神经代谢物的变化.戒断后遗传物质的变化是磁共振波谱动态变化的可能机制之一,观察血液中炎性因子水平在戒断后的变化情况可以间接反映患者戒断后脑内炎性因子的变化状况,这也能更好地解释磁共振波谱变化.未来利用现代遗传学的方法、血液中炎性因子水平以及磁共振波谱技术三者结合,能更准确地判断酒精使用障碍患者戒断后神经代谢物水平的动态变化,也能在患者戒断后和健康人群中未出现躯体症状和大脑结构变化前起到预测作用,并为进一步了解酒精成瘾的生物学机制提供参考.