甲状腺微小乳头状癌侵袭性危险因素的研究进展

摘要

甲状腺微小乳头状癌(PTMC)是临床上常见的甲状腺恶性肿瘤,生物学行为相对惰性,随着影像学的发展,近年来其检出率亦逐渐升高.PTMC患者多数预后良好,发生远处转移少且较晚,但仍有部分患者转变为侵袭性癌,常侵犯周围组织,转移较早,并具有较高的病死率,因此对高侵袭性的PTMC治疗不足将严重影响患者预后.目前,PTMC侵袭性的发生机制尚未阐明,其相关危险因素多而繁杂,且各因素间亦可能存在交叉影响,这一直是近年来研究的热点.%Thyroid papillary microcarcinoma ( PTMC) is a common malignant tumor of the thyroid in clinical .Its biolog-ical behavior is relatively inert ,with the development of imaging ,the detection rate of PTMC is significantly higher in recent years.Most of the patients with PTMC have good prognosis ,with less and late distant metastases and lower mortality rate , however , some cases still turn into aggressive cancer , which often invade surrounding tissues , with earlier metastasis and a high mortality rate,therefore,the lack of treatment of highly aggressive PTMC will seriously affect the prognosis of the patients.At present,the pathogenesis of aggressive PTMC has not been elucidated ,and the related risk factors are also numerous and complicated with cross effects between various risk factors ,which has been the focus of the research in recent years.