肠道菌群对免疫系统影响的研究进展

摘要

Gut Microbiota are key components of human body.And the complex intestinal microbial ecology is closely related with immune system of organisms.Intestinal microbes have a significant effect on extra-intestinal immune system,innate immunity,specific immunity and even autoimmune diseases.Physicochemical and biological stimulus from outside or our body can break the dynamic equilibrium between normal intestinal microflora and human organisms,resulting in the change of intestinal flora varieties and quantities.Intestinal disorder may plays an important role in the formation of a variety of immune diseases.%肠道菌群是机体的重要组成部分,与免疫系统的关系十分密切.肠道微生物可以对免疫系统,包括全身性的固有免疫、特异性免疫甚至自身免疫疾病产生影响.来自于机体内外的理化刺激和生物刺激会打破正常菌群与人体之间的动态平衡,菌群数量和种类的改变都会导致肠道内菌群的紊乱,多项研究表明,肠道菌群紊乱可能在多种免疫疾病的形成中起着重要作用.