加巴喷丁对绝经后 MPS 的临床疗效观察

摘要

Objective To discuss the clinical effect of gabapentin tablets on postmenopausal menopausal syndrome(MPS). Methods 122 cases with postmenopausal MPS were divided into 2 groups:observation group and experiment group,61 in each;oral administration of tibolone was made to cases in observation group,while oral administration of gabapentin tablets to cases in experiment group;a comparative study was made between the 2 groups on Kupperman scores,scores of anxiety and depression,sleeping quality and side-effect of the patients at the time point of before drug administration,30 days,60 days and 90 days after drug administration. Results Kupperman scores of the patients in experiment group at each time point were lower than those of the patients in observation group, and 90 days after drug administration,the scores in experiment group dropped down to 9. 3 ± 1. 5,while those in observation group down to 16. 1 ± 3. 3,the difference between the 2 groups was of statistical significance(P ﹤ 0. 05);the scores of anxiety,depression and sleeping quality of the patients in experiment group decreased much more than those of the patients in observation group(P ﹤ 0. 05);the occurrence of side effects in observation group was 24. 2% ,much higher than that in experiment group of 9. 1%(P ﹤ 0. 05). Conclusions Oral administration of gabapentin tablets makes obvious improvement in women with postmenopausal MPS,leads to a lower occurrence of side effect and adds no more cost for drug therapy;it is worthy of wider clinical application.%目的：探讨加巴喷丁片对绝经后妇女更年期综合征（MPS）的临床效果。方法根据随机数字表法将122例患有绝经后 MPS 的患者分为观察组和实验组，每组各61例，观察组给予口服利维爱片，实验组给予口服加巴喷丁片，分别于给药前和给药后30、60、90 d 时，比较两组的 Kupperman 得分、焦虑、抑郁、睡眠情况和不良反应。结果实验组的 Kupperman 评分在各时间点均低于观察组，治疗90 d 后，实验组的评分降至（9.3±1.5）分，观察组评分降至（16.1±3.3）分，组间比较差异均有统计学意义（P ﹤0.05）；实验组的焦虑、抑郁及睡眠质量评分均较对照组降低明显（P ﹤0.05）；两组的不良反应发生率分别是24.2％、9.1％，对照组明显高于实验组（P ﹤0.05）。结论口服加巴喷丁片对绝经期妇女 MPS 有明显的改善作用，不良反应发生率较低，且不会提高药物治疗费用，值得在临床推广应用。