不同剂量辛伐他汀治疗高脂血症的临床疗效观察

摘要

目的：观察分析不同剂量的辛伐他汀治疗高脂血症的临床疗效，为临床合理用药提供参考。方法：选取2009年1月-2012年12月本院收治的高脂血症患者382例，双盲法随机分为小剂量组（辛伐他汀20 mg/d）和大剂量组（辛伐他汀40 mg/d），每组各191例。连用8周，观察两组治疗前后的胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）水平的变化，比较两组疗效，监测不良反应。结果：大剂量组的TC、LDL-C、HDL-C、TG水平较小剂量组均改善明显（P<0.05）；大剂量组总有效率为89.53%，优于小剂量组的78.01%（P<0.05）；两组均表现出良好耐受性，未发现严重不良反应。结论：大剂量辛伐他汀治疗高脂血症疗效确切，安全性较高。%Objective:To observe and analyze the clinical curative effect of different doses of simvastatin treatment on hyperlipidemia,to provide reference for clinical rational drug use. Method:382 patients with hyperlipidemia in our hospital from January 2009 to December 2012 were selected and divided into low-dose group(20 mg/d)and high-dose group(40 mg/d)by double-blind randomized,each group had 191 cases. Ed eight weeks,observed changes of cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG)level of two groups before and after treatment,compared the clinical curative effect of two groups,monitored the adverse reactions.Result:TC,LDL-C,HDL-C, TG levels of High-dose group were improved significantly than small dose group(P<0.05);High-dose group total effective rate was 89.53%and better than that of small dose group(78.01%)(P<0.05);Both groups showed good tolerability,found no serious adverse reaction.Conclusion:High-dose simvastatin treatment of hyperlipidemia has curative effect,high safety.