透明质酸钠/魔芋葡甘聚糖多孔支架的仿生矿化研究

摘要

Porous scaffolds were prepared with sodium hyaluronate (SH) and Konjac glucomannan (KGM) via gellation method. Ammonia was used as crosslinker in the gellation process. The SH/KGM composites were pretrea-ted with calcium containing sollution and then biomimetic mineralized in simulated body fluid (SBF). The bvo-mine-ralized composites were characterized by XRD, EDS and SEM analysis. The results showed that hydroxyapatite crystals were already formed on the surface of the SH/KGM, and the hydroxyapatite particles were spherical with low crystallinity and small diameters. Meanwhile, it was observed that the mechanical strength and degradation rate increased after the scaffolds were bio-mineralized. Therefore, the bio-mineralized SH/KGM porous scaffolds are a novel kind of bone substitution materials with great potentials.%以魔芋葡甘聚糖(KGM)、透明质酸钠(SH)为主要原料,氨水为交联剂,制备SH/KGM多孔支架材料.将支架用钙盐溶液进行预钙化处理后,在模拟体液(Simulated body fluid,SBF)中浸泡仿生.仿生矿化后,对支架进行XRD、EDS、SEM分析.结果表明,仿生矿化后的SH/KGM多孔支架材料表面有圆球状羟基磷灰石颗粒沉积,且结晶度低、颗粒小；支架抗压强度及体外降解率均有相应的提高,是一种具有发展潜力的新型骨修复材料.