The Changes of Left Ventricular Form and Function After Closure of Moderate-to Large-sized Patent Ductus Arteriosus Using Domestic-made Occluder

摘要

Objectives To evaluate thechanges of the left ventricular form and function afterclosure of moderate- to large-sized patent ductusarteriosus (PDA) using domestic-made occluder.Methods 22 patients with PDA underwent proceduresuccessfully using the domestic-made occluder. Themean PDA minimal (pulmonary end) diameter byaortography was 8.01±2.47 mm (range 4 to 15.5mm).All patients underwent transthoracic echocardiography(TTE) study before the procedure and the following 48hours, 3 months after procedure. Results All patientshad been implanted the domestic-made occluderssuccessfully with no haematolysis, infectiveendocarditis, recanalization and other complications.At 3 months, mean LVED was decreased to 50.05±6.55mm, compared to the pre-procedure (55.67 ±8.48mm) , P < 0.01. After 48 hours of the procedure, meanLVEDD and LVESD decreased significantly (156.22±51.40 mL vs. 121.28±35.73ml, 57.16±32.07 mL vs.45.88±15.97 mL), P<0.05. At 3 months, LVEDDdecreased to 110.93±15.08ml, LVSV reached 73.50±9.19 mL, compared to the pre-procedure, P < 0.01.LVESD decreased to 37.43±10.44 mL at 3 months, P<0.05. Conclusions Closuring of moderate- to large-sized PDA using domestic-made occluder is effectiveand safe. After procedure, left ventricular form andfunction improved.