Objective To investigate the differential diagnosis significance of high and low grade serous ovarian cancer with carbohydrate antigen 125 ( CA125 ). Methods A total of 128 patients with ovarian tumors were retrospectively analyzed. The serum levels of CA125 of patients with high and low grade serous ovarian cancer and cystadenocarcinoma were determined preoperatively. Results Serum levels of CA125 among the high and low grade serous ovarian cancer patients were significantly higher than those of serous cystadenocarcinoma patients, respectively (P =0.002,P = 0. 003). The serum levels of CA125 between the high and low grade serous ovarian cancer patients showed no statistical significance (P =0. 426). Conclusions Serum CA125 plays an important role in the differential diagnosis of malignant ovarian tumors, but it cannot identify the high and low grade serous ovarian cancer.%目的 探讨血清糖类抗原125(CA125)测定对卵巢浆液性上皮良恶性肿瘤间及高、低级别浆液性癌间鉴别诊断的价值.方法 回顾性研究128例卵巢肿瘤患者的病例资料.比较高级别、低级别浆液性上皮性卵巢癌患者与浆液性囊腺瘤患者各组间术前血CA125值.结果 高级别、低级别浆液性上皮性卵巢癌患者术前血CA125值均高于浆液性囊腺瘤患者(P=0.002、P=0.003).高级别与低级别浆液性上皮性卵巢癌患者之间术前血CA125值相比差异无统计学意义(P=0.426).结论 血清CA125测定对卵巢良恶性肿瘤的鉴别具有意义,但对高级别和低级别浆液性上皮性卵巢癌的区分没有作用,需寻找更好的血清学指标来鉴别二者.
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