目的 分析探讨丙种球蛋白联用泼尼松治疗重症肌无力临床疗效及炎性因子的影响.方法 选取2012年9月至2015年9月在该院神经内科接受治疗的96例重症肌无力患者,分成观察组和对照组各48例.对照组患者应用泼尼松予以治疗,观察组则在对照组基础上应用丙种球蛋白给予5d的治疗.两组患者均连续治疗4个星期.观察、比较两组患者的临床效果、治疗前后调节性T细胞、肿瘤坏死因子(T NF-α)和白细胞介素-2(IL-2)等水平的变化情况.结果 经过相应的治疗之后,观察组患者的总有效率为95.8%,明显高于对照组的83.3%,组间比较差异有统计学意义(P<0.05);两组患者的定量重症肌无力评分均较治疗前明显提高,差异有统计学意义(P<0.05);两组患者的调节性 T 细胞、T NF-α和IL-2水平较治疗前均明显降低,差异有统计学意义(P<0.05).结论 丙种球蛋白联用泼尼松治疗重症肌无力患者能够获得良好的治疗效果,改善其免疫紊乱情况,降低炎性细胞因子水平,具有重要的临床意义.%Objective To analyze and investigate the clinical effect of gamma globulin combined with prednisone in the treatment of myasthenia gravis(MG)and its influence on inflammatory factors.Methods Ninety-six cases of MG in the hospital from Sep-tember 2012 to September 2015 were selected and divided into the observation group and control group,48 cases in each group.The control group was treated with prednisone,while on this basis the observation group used gamma globulin for 5 d.The two groups were treated for continuous 4 weeks.The clinical effects and changes of regulatory T cells,tumor necrosis factor(TNF-α)and infer leukin(IL-2)levels before and after treatment were observed and compared between the two groups.Results The total effective rate after the corresponding treatment in the observation group was 95.8%,which was significantly higher than 83.3% in the con-trol group,the difference between the two groups was statistically significant(P<0.05);the quantitative myasthenia gravis(QMG) score in the two groups were all significantly improved compared with before treatment,the difference between them was statistical-ly significant(P<0.05);of the levels of regulatory T cells,TNF-α and IL-2 after treatment in the two groups were all significantly decreased compared with before treatment,the difference were statistically significant(P< 0.05).Conclusion Gamma globulin combined with prednisone in the treatment of MG can obtain good therapeutic effect,improves the immune dysfunction situation,re-duces the inflammatory factors levels and has an important clinical significance.
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