叶酸及日光浴对老年H型高血压患者血清同型半胱氨酸和血压水平的影响

摘要

Objective To investigate the effect of folic acid and sun bath on the serum homocysteine(Hcy) and blood pressure level in elderly H-type hypertension.Methods One hundred and fifty cases of mild to moderate H-type hypertension were randomly divided into the control group,intervention group and combined group.The control group was given the routine treatment of hypertension;the intervention group was given oral Folic Acid Tablets 5 mg/d on the basis of conventional therapy and the combined group took 30 min sun bathing on the basis of oral Folic Acid Tablets 5 mg/d and conventional anti-hypertensive therapy;the blood pressure and serum Hcy level in 3 groups were measured before treatment and at 12 weeks after treatment.Results Compared with before treatment,the systolic and diastolic blood pressures after treatment in 3 groups were significantly decreased(P＜0.05),the serum level of Hcy in the intervention group and combined group were significantly decreased (P＜0.05),while which in the control group had no significant change(P＞0.05);in the comparison after 12-week treatment,the blood pressure and serum Hcy level in the combined group were significantly lower than those in the intervention group and the control group(P＜0.05),while serum Hcy level in the intervention group was significantly decreased as compared with the control group(P＜0.05),while no statistically significant difference in blood pressure levels was found between these two groups(P＞0.05).Conclusion Oral folic acid and appropriate sun bath on the basis of routine anti-hypertension can significantly reduce blood pressure and serum Hcy levels in the elderly patients with H-type hypertension,and the sun bath has a positive significance for the prevention and treatment of H-type hypertension.%目的 探讨叶酸及日光浴对老年H型高血压血清同型半胱氨酸(Hcy)和血压水平的影响.方法 入选老年轻中度H型高血压患者150例,随机分成对照组、干预组、联合组3组.对照组给予高血压常规治疗;干预组在常规治疗的基础上,给予口服叶酸片5 mg/d;联合组在常规降压治疗和口服叶酸片5mg/d的基础上,每天日光浴30 min;3组均在治疗前和治疗12周后测量血压和检测血清Hcy水平.结果 与治疗前相比,治疗12周后3组的收缩压和舒张压均明显降低(P＜0.05),干预组和联合组的血清Hcy水平均明显降低(P＜0.05),而对照组的血清Hcy水平无明显变化(P＞0.05).治疗12周后3个组相比较,联合组血压和血清Hcy水平均明显低于干预组和对照组(P＜0.05);而干预组血清Hcy水平较对照组明显降低(P＜0.05),两组患者血压水平差异无统计学意义(P＞0.05).结论 在常规降压的基础上口服叶酸及适量日光浴可显著降低H型老年高血压患者血压和血清Hcy水平,日光浴对H型老年高血压的防治有积极意义.