KK-Ay/Ta小鼠的相关生物学特性测定

摘要

目的 对KK-Ay/Ta小鼠进行生物学特性研究.方法 随机选取实验鼠配对繁殖,统计繁殖性状数据,并对其生长曲线、空腹血糖、随机血糖以及糖耐量进行测试.结果 KK-Ay/Ta小鼠从3周龄开始体重迅速增加,显示中度肥胖和糖尿病症兆,随着年龄增大其血糖值逐步上升呈现中度高血糖趋势.结论 KK-Ay/Ta小鼠是一种中度高血糖、高度胰岛素抵杭,胰岛功能不足且伴随肥胖的适用于Ⅱ型糖尿病研究的动物模型.%Human infected with human immunodeficiency virus (HIV-1) always progress to AIDS after a variable period of latency. However, African green monkeys (AGM) with high levels of virus do not show any signs of AIDS after natural infection with simian immunodeficiency virus (SIV). This elicited interest of researchers to use AGM in studies on the cellular and molecular mechanisms to control virus replication and disease progression. In this paper, recent progresses in this field were briefly reviewed.