鲨烯对谷氨酸钠诱发肥胖大鼠相关血液生化指标的影响

摘要

Objective To evaluate the effect of squalene on body fat and organ weight in male obese rats treated with MSG (Monosodium glutamate).Methods Thirty male Wistar rat were randomly divided into 2 groups,the model of the obesity(n=20) and the control group (n=10) at equivalent volume of saline during the same period.After weaning, the trial groups fed with squalene-containing ( 1000 mg/kg) diet orally and model group given a regular control diet as the same as negative control group.All rats were euthanized at 22 nd week.The concentration of blood fat and blood serum index were measured.Results Compared with the model control group the blood glucose, cholesterol,triglyceride of the squalene treated group rat were significant lower (P＜0.05), LDL-C and HDL-C were lower but no significant differece (P＞0.05), and Leptin and testosterone were higher (P＜0.05).Conclutions The squalene may counteract increases in body fat, reduce blood glucose, cholesterol,triglyceride, LDL-C and HDL-C, increase Leptin and testosterone in MSG -obese rats.%目的 探讨口服鲨烯对谷氨酸钠(Monosodium glutamate,简称为MSG)致肥胖大鼠的脂肪代谢以及血液指标的影响.方法 选择30只新生Wistar雄性大鼠,20只用于建立MSG肥胖大鼠模型,10只作为阴性对照组(注射等量生理盐水).断奶时将MSG大鼠随机分成试验组和对照组,分别饲喂含有鲨烯(1000 mg/kg)的饲料和基础饲料.测定22周龄时大鼠体重、血脂含量、血清指数.结果 与模型对照组相比,试验组血糖、胆固醇、甘油三醋含量显著降低(P<0.05),LDL-C和HDL-C均偏低且无显著差异(P>0.05),血清Leptin和辜酮含量显著上升(P<0.05).结论 鲨烯能够有效的拮杭MSG引起的肥胖,降低血糖、胆固醇、甘油三醋、LDL-C和HDL-C含量,提高血清Leptin和辜酮含量.