量子点的急性毒性及动力学初步观察

摘要

Objective To study the acute toxicity and the distribution of quantum dots in rats.Methods Six rats underwent quantum dots injection at the subcutaneous of upper limbs while the other six rats underwent physiological saline injection at the same sites. Two weeks observation and postobservation dissection were done on all of the twelve rats to confirm if there were any abnormities. The distribution of quantum dots was measured by inductively coupled plasma-mass spectrometry. Results No apparent toxicity was seen during two weeks' observation. The results of Cadmium assay showed that quantum dots mainly accumulated in the livers, spleens and kidneys of the rats. Conclusions The toxicity of quantum dots can be affected by many factors, which remain further research.%目的 研究量子点在大鼠体内脏器分布规律及大鼠对量子点的急性毒性反应.方法 取12只大鼠,6只右前肢皮下注射量子点,6只注射生理盐水对照.注射后饲养2周,记录一般状况,解剖观察器官有无异常.测试主要器官内镉元素含量,评价量子点在体内脏器分布规律.结果 实验组和对照组大鼠比较,一般状况无明显不同和异常,没有表现出急性毒性反应.量子点主要分布于肝脏,肾脏和脾脏.结论 量子点毒性与多种因素有关..