高山红景天总甙抗衰老作用机理的实验研究

摘要

[目的]观察红景天总甙抗衰老作用.[方法]红景天总甙按3.0g/kg、1.5g/kg、0.75g/kg灌胃给予老年大鼠30d,测血清丙二醛(MDA)含量,脑组织脂褐质(Lf)含量及血清超载化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性.[结果]红景天总甙三剂量组均能明显降低老年大鼠血清MDA含量及脑组织Lf含量,提高血清SOD、GSH-Px活性.[结论]红景天总甙可能通过改善自由基代谢发挥抗衰老作用.%[Objective] To observe the delaying aging of Crenulin Saponins. [Method] Perfuse Crenulin Saponins to senile rats at 3.0g/kg, 1.5 g/kg,0.75 g/kg for 30d, measure MDA, Lf, SOD and GSH-Px activity. [Result] Crenulin Saponins can markedly reduce MDA and Lf content, increase SOD and GSH-Px activity. [Conclusion] It may exert delaying aging by improving radical metabolism.