THE STUDY OF POPULATION GENETIC RELATION AMONG TEN ETHNIC GROUPS IN NORTHWEST CHINA

摘要

Objective To investigate the genetic relation among ten ethnic groups in northwest China. Methods Allele frequencies of six STR(short tandem repeat ) loci in D13S1358, VWA, FGA, D5S818, D13S317, and D7S820 were collected from Lasa Tibetan, Changdu Tibetan, Xian Han, Gansu Dongxiang, Gansu Yugu, Xinjiang Uygur, Ozbak, Kirgiz, Sibe, Ningxia Hui by the results of State Key laboratory, Forensic Science Department, school of medical, Xian Jiaotong University and internet biological information data bank, and compared with that of the Mongolian, Zhuang in China, and White and Negro in USA. The polymorphism index (H, DP, PPE, PIC) and genetic distance, then the phylogenetic tree of all population were reported. Results The resulting tree topology exhibited strong geographic and racial partitioning consistent with that obtained with HLA and classical genetic polymorphisms. Conclusion The results suggest that forensic STR loci may be particularly powerful tools and provide the necessary fine resolution for the reconstruction of recent human evolutionary history.