目的 探讨一种自供电植入式神经刺激器的可行性.方法 基于热释电效应和红外光的穿透性,构建一种植入式神经刺激器,测试其在体外红外光驱动下的电学性能;并进行体内和体外的生物实验,观察电刺激下的蛙腓肠肌的电刺激响应,以及小鼠心脏的电刺激响应.结果 构建的植入式神经刺激器在红外光的间歇照射下会产生可控的神经电刺激信号,输出的神经电刺激电压可达到1.2V;用该神经电刺激器分别直接刺激小鼠心脏和蛙腓肠肌,可见小鼠心电图的变化,蛙腓肠肌会发生明显收缩,且张力值随体外控制光强度的增大而增大;在体外控制光的驱动下,植入蛙皮下的该神经电刺激器能有效刺激蛙的腓肠肌,使之发生可控收缩.结论 体外光驱动的植入式神经电刺激器可以实现电刺激器的自供电,且电刺激幅值、波形可随光照强度和频率可调,为植入式设备的供电提供了解决方案.%Objective To explore the feasibility of fabricating a self-powered and implantable stimulator . Methods Based on pyroelectric effect and high penetrability of infrared ray , an implantable stimulator was designed and fabricated .The electrical performance of stimulator was measured under infrared ray illumination .We conducted the animal experiments in vitro and in vivo to observe the response of gastrocnemius contraction under stimulation .Results The stimulator could output the electrical signal under the periodical infrared ray illumination .The output voltage and current were proportional to the intensity of infrared ray ,which could reach up to 1 .2 V . A real-time electrical stimulation of frog gastrocnemius was conducted and obvious contraction was observed .The tension values increased with the increase of infrared intensity .We further carried out the in vivo experiment with a frog in order to evaluate the performance of the stimulator after being implanted into the body . The gastrocnemius would also be made to contract even though the infrared intensity decayed when through the skin .Conclusion The proposed pyroelectric stimulator can be self-powered and controlled through near-infrared illumination .This study can provide some guidance for solving the problems of implantable power .
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