目的分析单次激发快速自旋回波-流动敏感反转恢复序列（SSFSE-FAIR）与平面回波-流动敏感反转恢复序列（EPI-FAIR）所测量的健康肾脏的相对血流量值（rBFV），评价两种动脉自旋标记（ASL）序列在正常肾脏检查中的应用价值。方法前瞻性分析40例符合纳入标准的受试者的rBFV。采用3.0T磁共振扫描仪扫描。按3种方式采集图像：EPI-FAIR屏气法、SSFSE-FAIR屏气法及SSFSE-FAIR自由呼吸法。结果SSFSE-FAIR自由呼吸法可定量区分肾脏皮髓质。皮质rBFV：111.48±9.23；髓质rBFV：94.98±3.38；SSFSE-FAIR屏气法及EPI-FAIR不能定量区分肾脏皮髓质。EPI-FAIR皮髓平均rBFV为178.50±17.17，95%置信区间：167.59~189.41。结论 SSFSE-FAIR屏气法及EPI-FAIR空间分辨率低，无法区分肾脏皮髓质，可粗略评价肾脏灌注情况。SSFSE-FAIR图像空间分辨率较高，可区分肾脏皮髓质结构，可初步评判肾脏皮髓质的灌注状态。%Objective To analyze the renal relative blood flow value (rBFV) and image quality in normal adults using single-shot fast spin echo, flow sensitive invention recovery (SSFSE-FAIR) magnetic resonance (MR) sequence and echo planar imaging, and flow sensitive invention recovery (EPI-FAIR) MR sequence, and assess its value for clinical application in routine renal examination. Methods Forty volunteers (25 male and 15 female adults, aged 30 to 62 years) with normal renal function were included in this prospective study. All the subjects underwent 3.0 Tesla MR scanning using 3 MR scan modes, namely breath-holding EPI-FAIR, breath-holding SSFSE-FAIR and free breathing SSFSE-FAIR. Results SSFSE-FAIR without breath-holding was capable of differentiating the renal cortex and medulla with the corresponding rBFVs of 111.48 ± 9.23 and 94.98 ± 3.38, respectively. Breath-holding SSFSE-FAIR and EPI-FAIR failed to distinguish the borders of the renal cortex and medulla. The EPI-FAIR rBFV of mixed cortex and medulla value was 178.50±17.17 (95%CI:167.59, 189.41). Conclusion Breath-holding SSFSE-FAIR and EPI-FAIR can not distinguish the renal cortex and medulla due to a poor spatial resolution but can be used for rough evaluation of renal blood perfusion. Free breathing SSFSE-FAIR with an improved spatial resolution allows evaluation of the status of renal perfusion of the cortex and medulla.
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