纳米铂黑修饰微电极阵列在神经电生理检测中的应用研究

摘要

目的:研究纳米铂黑修饰微电极阵列在神经电生理信号检测中的应用及其检测性能.方法:采用微电子机械系统(MEMS)工艺制备出用于神经电生理检测的微电极阵列,采用电化学沉积法在微电极阵列表面修饰纳米铂黑颗粒,通过扫描电镜观察修饰层的表面形貌.在同一测试环境下对比裸电极与修饰电极的噪声水平.利用修饰电极进行神经电生理信号的检测.结果:电化学沉积法制备的纳米铂黑颗粒在微电极表面分布致密而均匀.修饰铂黑后微电极信噪比可提高到原来的2.5倍,实验中能分辨出幅度在10 μV左右的微弱电生理信号.结论:通过在微电极表面修饰纳米铂黑,可有效改善电极性能,提高神经电生理信号检测的信噪比.%Objective:To study the application and performance of microeleetrode arrays with nano platinum black deposition on neural electrophysiological recording. Methods: Microelectrode arrays for neural electrophysiological recording were fabricated by process of micro-electro-mechanical systems(MEMS) technology. Platinum black nano particles were electrochemically deposited onto the surface of microelectrodes. Morphology of the deposited film was observed by scanning electron microscope. Background noise of the microelectrodes with and without platinum black deposition was tested under the same environmental condition. Neural electrophysiological signals were recorded by the platinum black deposited microelectrode. Results: The electrochemically deposited platinum nanoparticles distributed compactly and uniformly on the microelectrodes. Signal to noise ratio of the microelectrodes can be improved by 2.5 times with platinum deposition. Electrophysiologieal signals as weak as 10 μV were successfully detected by deposited mieroelectrodes. Conclusion: Nano platinum black deposition can effectively improve the mieroeleetrode performance and increase the signal to noise ratio of electrophysiologieal recording.