ABCB1基因多态性对抗抑郁药物疗效影响的Meta分析

摘要

Objective To explore the correlation between the ABCB1 3435T＞C(rs1045642)and 2677T＞G/A(rs2032582)and the efficacy of antidepressant drugs by Meta-analysis. Methods Pubmed,Embase,Cochrane Library and CNKI databases were searched for screening studies on the association between ABCB1 gene polymorphism and antidepressant efficacy. Stata software was used to ana-lyze the data,and the pooled OR value and 95% confidence interval(95%CI)were calculated to determine the association. Results Eight articles were enrolled according to the literature inclusion criteria and exclusion criteria. The pooled results showed that 3435T＞C was not associated with response rate (CC+CT vs TT:OR＝0. 90,95% CI 0. 53-1. 52;CC vs CT+TT:OR＝0. 95,95%CI 0. 61-1. 47)or remission rate(CC+CT vs TT:OR＝0. 59,95%CI 0. 28 -1. 24;CC vs CT+TT:OR＝0. 55,95%CI 0. 22 -1. 42). For the 2677T＞G/A,the SNP had no significant effect on the response rate of antidepressants(GG+GT vs TT,OR＝1. 03, 95%CI 0. 36-2. 93;GG vs GT+TT:OR＝1. 04,95%CI 0. 64-1. 68). Under the dominant model,2677T＞G/A was significantly associated with remission rate(GG+GT vs TT:OR＝0. 23,95% CI 0. 07-0. 75),but the association was not found under the reces-sive model(GG vs GT+TT:OR＝0. 7,95%CI 0. 32-1. 51). Conclusion ABCB1 gene polymorphism 3435T＞C (rs1045642)has no significant effect on the antidepressant efficacy,and 2677T＞G/A could affect the remission rate of antidepressant drugs.%目的 通过Meta分析的方法确定ABCB1 3435T＞C(rs1045642)和2677T＞G/A(rs2032582)与抗抑郁药物疗效之间的相关性. 方法 计算机检索Pubmed、Embase、Cochrane Library和中国知网全文数据库,检索的时间范围从建库至2017年8月14日.筛选研究ABCB1基因多态性与抗抑郁药物疗效之间相关性的文献.采用Stata软件对数据进行统计分析,以合并比值比(OR)和95%置信区间(95%CI)确定相关性. 结果 共纳入8篇文献.合并结果显示,3435T＞C与抗抑郁药物治疗抑郁症的应答率无关(CC+CT vs TT:OR＝0. 90,95%CI 0. 53-1. 52;CC vs CT+TT:OR＝0. 95,95%CI 0. 61-1. 47);与抗抑郁药物治疗抑郁症的缓解率也无关(CC+CT vs TT:OR＝0. 59,95%CI 0. 28-1. 24;CC vs CT+TT:OR＝0. 55,95%CI 0. 22-1. 42).对于2677T＞G/A,该SNP对抗抑郁药物治疗抑郁症的应答率无显著影响(GG+GT vs TT:OR＝1. 03,95%CI 0. 36-2. 93;GG vs GT+TT:OR＝1. 04,95%CI 0. 64-1. 68),在显性模型下,2677T＞G/A与抗抑郁药物治疗抑郁症的缓解率有显著关联(GG+GT vs TT,OR＝0. 23,95%CI 0. 07-0. 75),但在隐性模型下无显著关联(GG vs GT+TT:OR＝0. 7,95%CI 0. 32-1. 51). 结论 ABCB1基因多态性3435T＞C(rs1045642)对抗抑郁药物疗效无显著影响,2677T＞G/A可能影响抗抑郁药物治疗抑郁症的缓解率.