RE_2（HL）（L）（iso）·4H_2O与DNA作用的光谱研究

摘要

The DNA-binding properties of rare earth with 2-carbonyl pyruvic acid-salicylhydrazone（H3L） and isonicotinic acid（Hiso） were investigated using electronic absorption and fluorescence spectrometry.The results indicated that RE2（HL）（L）（iso）·4H2O（RE=La,Sm,Gd） bound to calf thymus DNA mainly by part intercalation including some electrostatic effection;while the last two complexes bound to DNA mainly by intercalation.%采用吸光光谱和发光光谱法研究了RE（NO3）3.nH2O（RE=La,Sm,Gd,Tb,Er）同2-羰基丙酸水杨酰腙（C10H10N2O4,简称H3L）和异烟酸（Hiso）形成的混配体配合物与小牛胸腺DNA的作用机理,研究发现RE2（HL）（L）（iso）.4H2O（RE=La,Sm,Gd）与DNA的作用方式是包括静电结合的部分插入,后两种配合物则是主要以插入方式结合。