贝前列素钠治疗雷诺现象的临床观察

摘要

Objective To observe the effectiveness and safety of Beraprost sodium in the treatment of Raynaud's Phenomenon .Methods 63 cases of Raynaud's Phenomenon patients were divided into treatment group (33 cases) and control group (30 cases).In treatment group, Beraprost sodium was implemented, in control group , Nifedipine Tablets was given .The advanced imaging technique was used to check the hemodynamics in the two groups.To observe the data of the average value of the index finger ulnar , radial palmar artery diameter (D), the systolic peak velocity (Vmax), pulsatility index (PI) and resistance index (RI).The symptom score, cold water test and the temperature recovery time were measured as a clinical indicator , hemodynamic data as the laboratory evaluation index .Results 11 cases were markedly effective and 13 cases were effective in the treatment group, the total efficiency was 72.73%which was higher than that in control group (P<0.05).In the hemodynamics , after treatment , the artery diameter ( D ) , peak systolic velocity ( Vmax ) were significantly increased compared with the treatment group before treatment and control group after treatment (P<0.05).The pulsatility index (PI), resistance index (RI) and I) compared with those before treatment and control group after treatment was significantly decreased, there were significant differences (P <0.05).Reflect the ulnar, high resistance and low compliance of radial palmar artery has improved significantly after treatment .Conclusions In the treatment of Raynaud's phenomenon , the use of oral beraprost sodium treatment , can significantly improve the symptoms of patients with acromegaly , increase blood flow and improve vascular compliance .%目的：本研究在于观察口服贝前列素钠治疗雷诺现象的临床疗效。方法63例雷诺现象患者随机分为对照组与治疗组，治疗组33例给予贝前列素钠片口服治疗，对照组30例给予硝苯地平片口服治疗，二组均应用高级血流成像技术患者进行血流动力学检查，取食指尺、桡掌侧2支动脉的血管内径（D）、收缩期最大流速（Vmax）、搏动指数（P I）、阻力指数（R I）的平均值作为观察数据。以症状评分、冷水试验、指温恢复时间测定作为临床疗效指标，血流动力学数据作为实验室评价指标。结果治疗组显效11例，有效13例，总有效率72．73％，较对照组明显增高，有显著性差异（P＜0．05）。在血流动力学方面，治疗组治疗后的血管内径（ D）、收缩期最大流速（ Vmax）较治疗组治疗前及对照组治疗后均有明显增加（ P＜0．05）；搏动指数（P I）、阻力指数（R I）较治疗前及与对照组治疗后相比较均有显著性降低（P＜0．05）。反映尺、桡掌侧2支动脉的高阻性和低顺应性经治疗后有明显好转。结论在治疗雷诺现象中，采用口服贝前列腺素钠治疗，可明显改善患者的自觉症状，增加肢端血流量，改善血管顺应性。