艾司西酞普兰与西酞普兰改善癫痫发作患者抑郁症状的对照研究

摘要

目的 探讨艾司西酞普兰与西酞普兰改善癫痫发作患者抑郁症状的效果.方法 将158例伴发抑郁症状的癫痫发作患者随机分为研究组(80例)和对照组(78例),研究组给予艾司西酞普兰系统治疗,对照组给予西酞普兰系统治疗,疗程均为4周.入组患者应用汉密尔顿抑郁量表(HAMD)与不良反应量表(TESS)在基线及治疗后第1、2、4周末分别评定疗效与不良反应.结果 与基线相比,研究组HAMD评分在第1周末即有显著性降低(P＜0.05),而对照组HAMD评分在第2周末才有显著性降低(P＜0.05).在治疗后的第1、2、4周末,研究组HAMD评分均低于对照组(P＜0.05).在治疗后的第4周末,研究组临床整体疗效优于对照组(P＜0.05).两组均未出现严重不良反应.结论 艾司西酞普兰和西酞普兰均可有效、安全地改善癫痫发作患者的抑郁症状,而艾司西酞普兰起效更快,疗效更好.%Objective To explore efficacy of escitalopram vs. citalopram in improving depressive symptoms of patients with epilepsy. Methods A total of 158 epilepsy patients with depressive symptoms were randomly divided into study group (80 cases) and control group (78 cases) treated with escitalopram and citalopram respectively for 4 weeks. The efficacy and side effects were assessed with Hamilton Rating Scale for Depression (HAMD) and Treatment Emergent Symptom Scale (TESS) at baseline and the end of the 1st, 2nd and 4 th week of treatment. Results Compared with the baseline, the total scores of HAMD in study group decreased significantly at the 1 st weekend (P < 0. 05 ) , while the significance appeared till the 2nd weekend in control group (P < 0. 05). The scores of HAMD in study group were significantly lower than those in control group at the 1st, 2nd and 4th weekend of treatment (P <0. 05). The global efficacy in study group was better than that in control group at the end of the treatment (P < 0. 05). No severe side effects happened in both groups and there was no significant difference in side effects between the two groups (P < 0.05). Conclusion Both escitalopram and citalopram are effective and safe in improving depressive symptoms of patients with epilepsy. Escitalopram takes effect faster and has better efficacy than citalopram.