咀嚼烟草与口腔癌的风险:系统评价与Meta分析

摘要

Objective:To systematically explore the relationship of chewing tobacco and oral cancer through the past related studies. Methods; Based on the theory and criterion of systematical assessment, studies about the relationship of chewing tobacco and oral cancer were retrieved by searching the databases of PubMed and ISI web of science ( up to April 2011). Related studies were selected by the selection criteria and quality assessment system, irrelevant studies were excluded, the relationship between chewing tobacco and oral cancer was evaluated and the public bias was also assessed in the Meta-analysis. Results: Ten eligible studies included heterogeneity, therefore random effect model was used in the Meta analysis. The effect size OR =4.93 and 95%CI(2. 22, 7.64). Conclusion:Chewing tobacco is a risk factor of oral cancer.%目的:通过既往相关研究,综合评价咀嚼烟草的食用与口腔癌之间的关联.方法:根据系统评价的原理和规范,检索Pubmed和ISI web of science(截至2011年4月)数据库,全面查找研究咀嚼烟草和口腔癌之间关系的文献,严格按照纳入、排除标准和质量评价体系,剔除不相关文献之后,采用Meta分析评估咀嚼烟草与口腔癌的关联性,同时评估发表偏倚.结果:纳入10篇文献,经检验文献存在异质性,采用随机效应模型,咀嚼烟草对口腔癌总的效应为OR =4.93,95％的CI为(2.22,7.64).结论:咀嚼烟草与口腔癌症有关联,且咀嚼烟草为危险因素.