低剂量胸部CT肺癌筛查同时探讨胸主动脉和冠状动脉钙化的流行病学

摘要

目的 探讨胸主动脉和冠状动脉钙化的流行病学,分析与肺癌相关的常见危险因素对胸主动脉和冠状动脉钙化的影响.方法 入选本院参加肺癌筛查项目的体检人群,共2 393例.用x 2检验分析胸主动脉和冠状动脉钙化的年龄、性别分布差异;用Logistic回归分析探讨与肺癌相关的危险因素对胸主动脉和冠状动脉钙化的影响.结果 胸主动脉钙化总阳性率为24.73％,其中主动脉弓钙化阳性率最高.冠状动脉钙化总阳性率为8.82％,左冠状动脉钙化阳性率高于右冠状动脉.胸主动脉和冠状动脉钙化阳性率均随年龄增长而增加,男性钙化阳性率高于女性(P＜0.05).吸烟者的胸主动脉及冠状动脉钙化阳性率高于不吸烟者,且吸烟量≥30包/年者阳性率高于吸烟量＜30包/年者(P＜0.05).与肺癌相关的危险因素中,年龄、吸烟、慢性支气管炎病史与胸主动脉和冠状动脉钙化相关.结论 低剂量胸部CT平扫肺癌筛查同时检出胸主动脉及冠状动脉钙化,能够评估健康筛查人群动脉粥样硬化的流行病学特征.%Objective To investigate the epidemiological characteristics of thoracic aorta and coronary calcification,and to analyze the effects of common risk factors on thoracic aorta and coronary calcification.Methods Low dose chest CT was performed in 2 393 asymptomatic subjects who underwent lung cancer screening.The chi-square test and Logistic regression analysis were used.Results The frequency of aortic calcification was 24.73％ in total 2 393 subjects.And the frequency of calcification was the highest in the arch.The frequency of aortic calcification was 8.82％,and the frequency of calcification was higher in the left coronary artery than the right coronary artery.The frequency of thoracic aorta and coronary calcification were increasing with age,and the frequency of calcification was higher in male than female (P ＜0.05).The frequency of calcification was higher in smokers than non-smokers,and the frequency of calcification was higher in smokers (≥30 capsules) than the smokers (＜30 capsules) (P＜0.05).The age,smoking and chronic bronchitis were associated with thoracic aorta and coronary calcification.Conclusion The detection of calcification of thoracic aorta and coronary in lung cancer screening using low dose chest CT can assess the epidemiological characteristics of atherosclerosis in healthy screening population.