基础焦虑状态对IVF/ICSI妇女妊娠结局影响的系统评价

摘要

Objective:This study was to examine whether baseline state and trait anxiety can affect the outcome of IVF/ICSI. Methods:The databases were searched to identity relevant articles. Studies were included if they agreed with the prior defined criteria, and not met the exclusion criteria. The data extraction was done by two reviewers independently, and the quality of each individual study was evaluated. Heterogeneity analysis was done by RevMan 5.0 software and measurement data was integrated. Results:①State anxiety had side effect on the IVF/ICSI outcome( WMDstate anxiaty= -2.51,95%CI -4. 58 - -0.44) ;②Trait anxiety had no effect on the IVF/ICSI outcome( WMDtralt antiety =2.57,95%CI -0.58 -7.87) ;③The shape of funnel plots did not reveal any evidence of funnel plot asymmetry, which meant no publication bias in this study. Conclusions:State anxiety hasside effect on the IVF/ICSI outcome. Thus, the psychological inter-rn ventions before IVF/ICSI treatment might improve some patients'chances of becoming pregnant. However,rntrait anxiety has no effect on the IVF/ICSI outcome.%目的:研究施行体外受精/卵细胞浆内单精子注射(IVF/ICSI)的不孕症妇女基础焦虑状态对其妊娠结局的影响.方法:全面检索与研究目的相关文献,根据纳入与排除标准选择原始研究.经两人独立提取数据,对文献进行质量评价.采用RevMan 5.0软件对所纳入的研究进行异质性分析,并对计量资料进行合并.结果:①状态焦虑对IVF/ICSI妊娠结局有负性影响(WMD状态焦虑=-2.51,95％ CI-4.58～-0.44)；②特质焦虑对IVF/ICSI妊娠结局无显著影响(WMD特质焦虑=2.57,95％CI -0.58～7.87)；③漏斗图分析未提示不对称分布,故纳入文献无发表偏倚.结论:对IVF/ICSI的不孕症妇女,在开始治疗前对患者进行心理干预可能改善治疗结局；小样本的研究合并后可以看出特质焦虑对IVF/ICSI妊娠结局并无显著影响.