目的：探讨雄激素受体（androgen receptor，AR）在人类表皮生长因子受体-2（human epidermal growth factor receptor-2，Her-2）过表达型乳腺癌中的表达及其与临床病理特征的关系。方法：免疫组化检测 AR在102例Her-2过表达型乳腺癌的表达情况，并分析其与Her-2过表达型乳腺癌临床病理特征的相关性。结果：AR 在Her-2过表达型乳腺癌阳性率为75．5％；AR阳性Her-2过表达型乳腺癌患者的淋巴结转移率及Ki-67阳性率较低（P＜0．05）；AR 表达在年龄、绝经状态、肿瘤大小、组织学分级、脉管癌栓、p53及 PCNA 是否阳性差异均无统计学意义（P ＞0．05）。结论：AR在Her-2过表达型乳腺癌中的表达率高；AR可能是Her-2过表达型乳腺癌潜在治疗靶点。%Objective To investigate the expression of AR and its relationship with clinicopathological features in human epidermal growth factor receptor-2(Her-2) enrich breast cancer. Mehtods The expression of AR was detected by immunohistochemical staining in 102 patients with Her-2 enrich breast cancer. The relationship between AR expression and its clinicopathological characteristics was analyzed. Results The positive rate of AR expression was 75.5%. Patients in the positive group had a lower level of lymph nodes and Ki-67 value (P < 0.05). However, no significant differences of AR expression were observed in age, menopausal status, tumor size, histological grade, vessel invasion, P53 and PCNA (P > 0.05). Conclusion AR was highly expressed in Her-2 enrich breast cancer, which may be a potential target for treatment of Her-2 enrich breast cancer.
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