回、汉族人群三种上消化道肿瘤与ABO血型的关系研究

摘要

Objective To analyze the distribution of ABO blood type in both Hui and Han patients and its relationship with three upper gastrointestinal cancers and to provide the theoretical basis for the diagnosis and evaluation of cancers.MethodsA total of 5190 cases confirmed by endoscopy or pathological diagnosis of esophageal cancer,cardia cancer,and gastric cancer patients were selected from the General Hospital of Ningxia Medical University from January 1,2003 to December 31,2012. During the same period,759 Hui and Han healthy volunteers were enrolled as the control group. All subjects were recorded the factors including the name,sex,ethnicity,blood type. SPSS 18.0 software was used to perform statistical analysis. Regression analysis was conducted using binary Logistic regression.ResultsThere was no significant difference in the distribution of ABO blood type between Hui and Han patients with esophageal cancer,cardia cancer,gastric cancer and normal group. In contrast with control group,increased risk of cardia cancer and gastric cancer was observed in type A blood group(OR=1.216,95%CI=1.030~1.544;OR=1.234,95%CI=1.025~1.486). In the Hui population,type A blood group increased the risk of cardia cancer compared with the corresponding control group(OR=1.602,95%CI=1.051~2.441).ConclusionThere was no significant difference in the distribution of ABO blood group between the three upper gastrointestinal cancer patients and the normal population. A blood group showed a tendency of the development of cardia cancer and gastric cancer. In the Hui population,A blood group demonstrated increased risks of gastric cancer.%目的 探究回、汉族三种上消化道肿瘤(食管癌、贲门癌、胃癌)患者ABO血型的分布以及其与肿瘤的关系,为肿瘤的诊断与评估提供理论依据.方法 选取于2003年1月1日-2012年12月31日在宁夏医科大学总医院住院治疗并经胃镜或病理诊断确诊为食管癌、贲门癌、胃癌的5190例患者为研究对象,同时纳入经体检证实的759名回、汉族健康人群为对照组,记录姓名、性别、民族、血型等.采用SPSS 18.0统计软件对数据进行分析.结果 ABO血型在回、汉族食管癌、贲门癌、胃癌患者以及正常人群间分布差异均无统计学意义(P>0.05).在贲门癌患者和胃癌患者A型血人群较正常A型血人群肿瘤发生的风险增加(OR=1.216,95%CI=1.030~1.544;OR=1.234,95%CI=1.025~1.486);贲门癌回族患者A型血人群较正常回族A型血人群肿瘤发生的风险升高(OR=1.602,95%CI=1.051~2.441).结论 回、汉族人群三种上消化道肿瘤患者ABO血型分布与正常人群分布无差异,A型血人群患贲门癌和胃癌的风险增加;在回族人群中,A型血人群患贲门癌风险增加.