聚5-羧基吲哚-聚乙交酯可降解导电共聚物的合成与表征

摘要

以N,N'-二环己基碳化二亚胺(DCC)为脱水剂、4-二甲氨基吡啶(DMAP)为催化剂,通过低温缩聚法合成可生物降解并导电的聚5-羧基吲哚(PICA)与聚乙交酯(PGA)的共聚物.合成的产物采用红外光谱仪(FT- IR)、核磁共振氢谱仪(1H NMR)、质谱仪(MS)进行表征.结果表明:产物经25 d降解了41.7％,测得掺杂的共聚物电导率为9.1×10-4 S/cm.将乳仓鼠肾细胞(BHK21)黏附于合成的齐聚物膜上,细胞增殖生长效果明显.%A novel degradable electroactive conducting oligomer of poly ( indole-5-carboxy lie acid) (PICA ) and hydroxyl-capped polyglycolide ( PGA) was synthesized by low-temperature polycondensation with N,N'-dicyclohexylcarbodiimide (DCC) as dehydrating agent and 4-dimethylaminopyridine (DMAP) as catalyst. The properties and the morphology of the oligomer were characterized by Fourier transform infrared spectrum (FT-IR) , nuclear magnetic resonance spectroscopy (' H NMR ) and mass spectrometry (MS). The oligomer degradation reached 41. 7% in weight in the first 25 d. The electrical conductivity of the doped oligomer was measured to be 9. 1 X 10 -4 S/cm. To investigate the biocompatibility of the oligomer, baby hamster kidney 21 cells (BHK2, ) were cultured on oligomer film. Results indicated that the oligomer could support BHK21 cell attachment and proliferation.