Sqh is involved in the regulation of Ci stability in Hh signaling pathway

摘要

Dear Editor,Hedgehog(Hh)pathway is widely involved in cell growth and differentiation during both vertebrate and invertebrate development.Malfunction of Hh pathway couldcausevarioushumandiseases,including birth defects and cancers.In Drosophila,Cubitus interruptus(Ci),the homologue of mammal Glioblastomas(Gli),is a key transcription factor of Hh pathway.The activity andstabilityofCi/Gliare regulatedbyHhconcentration,and further precisely induce downstream gene expressions.Previous studies have suggested that in the absence of Hh,full-length CiFL(Ci155)is partially degraded into the repressor form CiR(Ci75),which blocks downstream gene expressions(Chen and Jiang,2013),through Cul1-Slimb-based E3 ligase-mediated proteolysis(Aza-Blanc et al.,1997;Jia et al.,2002;Price and Kalderon,2002)。