中性粒/淋巴细胞比值在正常人群及不同分期膀胱尿路上皮癌患者中的意义

摘要

Objective:To evaluate the significance of neutrophil-lymphocyte ratio(NLR)in patients with bladder urothelial carcinoma(UC)and the normal population.Methods:A total of 117 patients with non muscle-invasive bladder cancer(NMIBC)and 54 patients with muscle-invasive bladder cancer(MIBC)were followed up and the other 100 healthy people was selected as control group.Depending on the level of NLR,use receiver operator charac-teristic curve(ROC curve)to determine the NLR cut-off value to distinguish between non muscle-invasive bladder cancer patients and muscle-invasive bladder cancer patients(3.3).Use the same method to determine the optimal NLR value to predict the recurrence and metastasis after different types of bladder cancer patients (NMIBC 2.6,MI-BC 3.4).The patient＇s T stage,G grade,tumor number,tumour size,recurrence time,3-year recurrence-free sur-vival rate and tumor - free survival time were collected. Results:The NLR value was significant between normal healthy people and the cancer patients.The NLR value was also significant between NMIBC patients and MIBC pa-tients.The difference of preoperative NLR value was significant in the tumor T stage,G grade,size,number of tumors and time of recurrence of NMIBC patients.NLR value was significant in the tumor T stage of MIBC patients.Conclu-sion:The NLR value is likely to provide an economically viable inflammatory marker for the patient＇s disease-assis-ted diagnosis and prognosis.%目的:评估中性粒细胞与淋巴细胞比率(neutrophil -lymphocyte ratio,NLR)在膀胱尿路上皮癌(urothelial carcinoma,UC)患者及正常人群中的意义.方法:随访非肌层浸润性膀胱癌患者(non muscle-inva-sive bladder cancer,NMIBC)、肌层浸润性膀胱癌患者(muscle-invasive bladder cancer,MIBC)和健康体检患者.根据受试者工作曲线(receiver operator characteristic curve,ROC)确定不同类型膀胱癌患者术后是否出现复发及转移的最佳NLR值以及膀胱癌患者中NMIBC患者区别MIBC患者的最佳NLR值.收集患者T分期、G分级、肿瘤数量、复发时间、3年无复发生存率、无瘤生存率.结果:NLR值在正常健康人群及癌症患者中存在差异,在NMIBC患者及MIBC患者中存在差异(P＜0.05).NLR值在NMIBC患者的肿瘤T分期、G分级、肿瘤大小、肿瘤数量、复发时间及无瘤生存时间中存在差异(P＜0.05),在MIBC患者的肿瘤T分期中存在差异(P＜0.05).结论:NLR值很可能为患者的疾病辅助诊断及预后提供一项经济可行的炎症标志物.