VEGF及KDR在大肠腺瘤和腺癌中的表达及意义

摘要

目的:探讨VEGF和KDR在大肠腺瘤和大肠腺癌中的表达及临床病理特征的关系.方法:大肠腺瘤和大肠腺癌组织标本各100例,采用免疫组织化学染色法检测VEGF和KDR在标本中的表达情况.结果:VEGF和KDR在大肠腺癌组中的阳性表达明显高于大肠腺瘤组(P<0.05);在正常大肠黏膜均未见VEGF和KDR表达的阳性染色;VEGF阳性表达组中KDR的阳性表达率为70%,显著高于VEGF阴性表达组中KDR的阳性表达率16%,两组比较有统计学意义(P<0.01).结论:大肠腺癌组织中KDR的表达与肿瘤大小、转移情况、浸润深度密切相关;VEGF和KDR在大肠腺瘤中的表达与患者的年龄、性别及分型均无相关性,而与增生程度相关(P<0.05).在大肠腺癌患者中VEGF及KDR表达更高,二者具有协同效应.%Objective: To explore the relationships between VEGF and KDR expression and clinical and pathological features in colorectal adenoma and adenocarcinoma. Methods: By using immunohistochemical staining to detect VEGF and KDR in 100 colorectal adenoma and 100 adenocarcinoma. Results: VEGF and KDR in colorectal cancer group was significantly higher than that of colorectal adenomas,( P<0.05 ); In the normal mucosa there was no expression of VEGF and KDR positive staining. KDR positive expression rate was 70% in VEGF positive expression group, KDR was significantly higher than the positive rate of 16% in VEGF negative expression group( P <0. 05 ). Conclusion: In colorectal adenocarcinoma KDR expression and tumor size, metastasis, depth of invasion are closely related; VEGF and KDR expression in colorectal adenomas with age, sex and type were not correlated, and correlated with the degree of proliferation ( P <0. 05 ). In patients with colorectal adenocarcinoma expression of VEGF and KDR was higher synergistic effect.