三维适形与调强放疗技术在胸上段食管癌放疗中的剂量学比较

摘要

Objective:To compare the difference between intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3DCRT) for patients with upper esophageal carcinoma.Methods:All 34 patients with upper esophageal carcinoma were treated by IMRT and 3DCRT individually,the difference of exposure dose between target area and critical organ was compared by dose volume histogram (DVH).Results:In terms of target dose uniformity and conformity,IMRT was much better than 3DCRT,IMRT reduced maximum dose of spinal cord,and the results were statistically significant (P ＜ 0.05) ;in the dose of lung and heart,V5 IMRT's higher than 3DCRT(P ＜0.05),and there was no difference in the dose of lung and heart (P ＞ 0.05).Conclusion:To the patients with upper esophageal carcinoma,IMRT was better than 3DCRT for its good dose uniformity and conformity.%目的:比较调强放疗技术(IMRT)和三维适形放疗技术(3DCRT)治疗胸上段食管癌的剂量学差异.方法:选择34例胸上段食管癌患者,对每例患者分别进行调强适形放疗和三维适形放疗,利用剂量体积直方图来比较两种计划中靶区及器官的剂量学差异.结果:IMRT在靶区适合度和靶区剂量均匀性方面均优于3DCRT,IMRT减少了脊髓最大所受剂量,差异均有统计学意义(P＜0.05)；双肺受照剂量V5 IMRT高于3 DCRT(P＜0.05),但是V20差异无统计学意义(P＞0.05).结论:对胸上段食管癌IMRT有更好的剂量适形性,优于3 DCRT放疗.