目的:探讨肝细胞癌中内质网分子伴侣GRP94的表达及其与肝癌分化程度、临床分期及淋巴结转移的关系.方法:采用免疫组织化学法分别检测肝癌组织、癌旁组织及正常肝组织GRP94的表达水平,结合临床病理特征于光学显微镜下用半定量法对结果进行统计分析.结果:正常肝组织、癌旁组织及肝癌组织均有GRP94的表达.表达水平随细胞分化的降低、肿瘤体积的增大及肿瘤转移而升高,但与患者性别和年龄无关.结论:GRP94的表达可能参与了肝癌的发生、发展,抑制GRP94的表达有可能会抑制肿瘤的生长.%Objective:To investigate the expression of GRP94 in hepatocellular carcinoma and its relationship with differentiated degree, clinical stage, and lymphatic metastasis of hepatocellular carcinoma. Methods: Immunohisto-chemical method was applied to detect the expression of GRP94 in hepatocellular carcinoma tissue, paracancerous tissue , and normal liver tissue respectively. The results were analyzed by semi — quantitative method under optical microscope combined with its clinical and pathological features. Results: GRP94 was expressed in all the three types of tissues. The expression level of GRP94 increased with the degrading cellular differentiation, increasing tumor volume, and tumor metastasis, but it has no relationship with the patients'gender and age. Conclusion; GRP94 may be involved in the occurrence and progress of hepatocellular carcinoma. Therefore, tumor cell growth may be inhibited by decreasing the expression of GRP94.
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