AFP阳性胃肝样腺癌15例临床分析

摘要

Objective:To investigate the treatment and prognosis of the hepatoid adenocarcinoma of the stomach ( HAS),and analyze serum alpha fetoprotein( AFP)clinical significance of HAS in diagnosis and prognosis. Meth-ods:Collected 15 cases of pathologically confirmed HAS with positive AFP. Results:The survival time of all 1 5 pa-tients was 3 . 1 ~2 4 months ,the average was 1 0 . 5 2 months . Serum AFP concentrations ranged from 2 5 . 2 3 to 13 500μg/L. Conclusion:AFP level of HAS fluctuate widely. And elevate AFP is an important clinical and pathologi-cal feature of HAS. It is very useful for the diagnosis and treatment of HAS. Its useful for the early diagnosis and moni-tor of recurrence and metastasis of tumor. The prognosis of HAS is very poor,especially for patients with liver metasta-sis or portal vein tumor thrombus. We should avoid operations for metastasis cases.%目的：探讨胃肝样腺癌患者的治疗以及预后，同时分析血清甲胎蛋白在诊断胃肝样腺癌及判断预后中的临床意义。方法：分析15例手术病理证实为胃肝样腺癌患者的临床资料。结果：15例患者，生存时间3.1~24个月，平均10.52个月，术前血清AFP浓度范围为25.23~13500μg/L。结论：胃肝样腺癌AFP 水平波动范围大，血清AFP 升高是胃肝样腺癌重要的临床病理特点，在胃肝样腺癌诊治中具有重要价值，可作为早期诊断的条件之一，同时可以用于监测肿瘤复发与转移。胃肝样腺癌预后极差，合并肝转移或者门静脉癌栓患者建议避免手术治疗。