Objective:To investigate the impact of the preoperative peripheral blood neutrophil - to - lymphocyte ratio(NLR)on postoperative prognosis of patients with primary hepatic cancer(PHC). Methods:Clinicopathologic data of 96 PHC patients undergoing transcatheter arterial chemoembolization(TACE)were analyzed retrospectively. Based on the preoperative neutrophil - to - lymphocyte ratio(NLR),the patients were divided into low NLR group (NLR < 2. 5)and high NLR(NLR≥2. 5)group. The overall survival time and progress - free survival time of the two groups were analyzed,and risk factors that would influence the prognosis of these patients were determined by uni-variate and multivariate analyses. Results:The median overall survival time for the entire group was 21. 1 months, which for high NLR group and low NLR group was 16. 0 and 23. 3 respectively. The difference in the overall survival between the two groups had statistical significance(P = 0. 002). The median progress free survival time for the entire group was 13. 8 months,which for high NLR group and low NLR group was 9. 6 and 17. 6,and there was statistically significant difference in the progression - free survival time between the two groups(P = 0. 011). Univariate analysis showed that liver function Child classification,BCLC staging,AFP,formation of psuedocapsule,blood supply,frequen-cy of TACE and NLR≥2. 5 were the risk factors for the postoperative overall survival time of PHC patients undergoing TACE(P < 0. 05),and liver function Child classification,BCLC staging,formation of psuedocapsule,blood supply and NLR≥2. 5 were the risk factors for the postoperative progress - free time of PHC patients undergoing TACE(P <0. 05). Multivariate analysis revealed that liver function Child classification,BCLC staging and NLR≥2. 5 were the independent prognostic factors for the survival of PHC patients undergoing TACE(all P < 0. 05),and BCLC staging and NLR≥2. 5 were the independent prognostic factors for postoperative progress - free time of PHC patients under-going TACE(P < 0. 05). Conclusion:Preoperative peripheral blood NLR can be used as a prognostic predictor of PHC patients undergoing TACE,and those with high NLR face a poor prognosis.%目的：探讨原发性肝癌（PHC）患者术前中性粒细胞/淋巴细胞比值（NLR）对预后的影响。方法：回顾性分析96例行经导管肝动脉栓塞化疗（TACE）术的 PHC 患者临床病理资料。根据术前 NLR 值，分为低NLR 组（NLR ＜2.5）和高 NLR 组（NLR≥2.5），分析两组患者总生存时间与无进展生存时间；并对其影响预后的危险因素行单因素与多因素分析。结果：全组介入术后，中位总生存时间21.1个月；其中术前高 NLR 组中位总生存时间16.0个月；术前低 NLR 组中位总生存时间23.3个月；两组中位生存时间差异有统计学意义（P=0.002）。全组患者中位无进展生存时间13.8个月，其中高 NLR 组中位无进展生存时间9.6个月，低 NLR组中位无进展生存时间17.6个月，两组中位无进展生存时间差异有统计学意义（P =0.011）。单因素分析显示：肝功能 Child 分级、BCLC 分期、AFP、假包膜形成、血供、TACE 次数、NLR≥2.5是影响 PHC 患者 TACE 术后总生存时间的危险因素（P ＜0.05）。肝功能 Child 分级、BCLC 分期、假包膜形成、血供、NLR≥2.5是影响PHC 患者 TACE 术后无进展生存时间的危险因素（P ＜0.05）；多因素分析显示，肝功能 Child 分级、BCLC 分期、NLR≥2.5是影响 PHC 患者 TACE 术后生存的独立预后因素（P ＜0.05）。BCLC 分期、NLR≥2.5是影响 PHC患者 TACE 术后无进展生存时间的独立预后因素（P ＜0.05）。结论：术前外周血 NLR 可作为 PHC 患者行 TA-CE 的预后指标，NLR 高者预后差。
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