自拟益气化痰汤联合姑息性化疗对晚期非小细胞肺癌患者近期生存率及生活质量的影响

摘要

目的：探讨自拟益气化痰汤联合姑息性化疗对晚期非小细胞肺癌（NSCLC）患者近期生存率及生活质量的影响。方法：选择2011年1月-2014年1月我院收治的晚期 NSCLC 患者94例。随机分为观察组（n=47）和对照组（n =47）。对照组仅采用姑息性化疗方案治疗，观察组在对照组基础上联合自拟益气化痰汤。对比分析两组疗效、生活质量、不良反应发生情况及随访6个月患者生存率。结果：两组化疗后躯体功能、情绪功能、社会功能、角色功能、认知功能以及整体生活质量评分均显著高于化疗前（P <0.05）；观察组化疗后上述指标评分高于对照组（P <0.05）；观察组近期总有效率显著高于对照组（P <0.05）；观察组白细胞减少、恶心呕吐、贫血发生率显著低于对照组（P <0.05），而血小板减少、外周神经毒性比较无统计学差异（P>0.05）。结论：自拟益气化痰汤联合姑息性化疗对晚期非小细胞肺癌疗效显著，可明显提高患者近期生存率，改善患者生活质量。%Objective:To investigate the effect of Yiqi Huatan Tang combined with palliative chemotherapy on sur-vival and quality of life in advanced non - small cell lung cancer patients. Methods:All 94 patients with advanced NSCLC were randomly divided into trail groups(n = 47)and control group(n = 47). The control group was treated with only palliative chemotherapy treatment,observation group combine with Yiqi Huatan decoction on the basis of the control group. Results:After chemotherapy,physical function,emotional function,social function,role function,cogni-tive function and overall quality of life scores were significantly higher than that before chemotherapy(P < 0. 05). Ob-served group after chemotherapy,the index score was higher(P < 0. 05),total effective rate was significantly higher (P < 0. 05). In observation group leukopenia,nausea,vomiting,anemia was significantly lower than the control group (P < 0. 05). But thrombocytopenia,peripheral neurotoxicity had no significant difference(P > 0. 05). Conclusion:Yiqi Huatan Tang combined with palliative chemotherapy for advanced non - small cell lung cancer can significantly improve the survival rate and the quality of life of NSCLC patients.