全身电子线照射治疗T3期蕈样霉菌病的近期疗效分析

摘要

目的:探讨全身电子线照射治疗肿瘤期蕈样霉菌病的近期疗效和不良反应.方法:我院2007-2016年收治的皮肤蕈样霉菌病患者11例,均经病理检查证实,中位年龄52岁,均为T3期患者,所有病人采用6Mev电子线全身照射,总剂量DT 36 Gy,残留病灶电子线局部加量放疗DT 10～20 Gy,放疗后有8例患者联合CHOP方案化疗2～4周期.结果:总有效率为100％,其中CR 72.7％ (8/11)、PR 27％(3/11)、平均生存时间10.8月,目前生存2例,不良反应主要有皮肤红斑、干燥脱屑、脱发、无汗、色素沉着及骨髓抑制等.结论:全身电子线照射治疗T3期蕈样霉菌病的效果是显著的,且不良反应可耐受,因此可作为局部晚期蕈样霉菌病的治疗选择.%Objective:To study the short term outcome and side effects of total skin electron beam therapy for T3 stage mycosis fungoides.Methods:11 mycosis fungoides patients were confirmed by pathology in our hospital between 2007-2016.The median age was 52 years old.All patients with T3 stage were treated by total skin electron beam therapy(TSEBT) with 6Mev electrons.The total dose was 36 Gy.Boost dose of 10 ～20 Gy was given to residual tumors.8 patients received chemotherapy of CHOP regimen for 2 ～ 4 cycles after radiotherapy.Results:Total response rate was 100％,and complete response rate was 72.7％ (8/11),and partial response rate was 27％ (3/11).Mean survival time was 10.8 months.2 patients were still survival now.The main adverse reactions such as skin erythema,dry and desquamation,alopecia,no sweat,hyperpigmentation and bone marrow suppression happened.Conclusion:TSEBT played an important role in the therapy of T3 stage mycosis fungoides and the adverse effect could be tolerable.Maybe it will be a good choice for locally advanced mycosis fungoides.