榄香烯乳联合顺铂胸腔灌注治疗恶性胸腔积液疗效及安全性的Meta分析

摘要

目的:系统评价榄香烯乳联合顺铂胸腔灌注治疗恶性胸腔积液的临床疗效和安全性.方法:以“榄香烯乳、顺铂、恶性胸腔积液”等为关键词,计算机检索如下数据库:Pubmed、CNKI、万方医学网、FMRS等,纳入榄香烯乳联合顺铂胸腔灌注治疗恶性胸腔积液的随机对照试验(RCT),并用RevMan 5.3软件进行Meta分析.结果:本文纳入6个研究,包括463例恶性胸腔积液患者,所有研究均采用随机对照方法.Meta分析结果显示,榄香烯乳联合顺铂胸腔灌注治疗恶性胸腔积液有效率优于单纯用顺铂胸腔灌注,差异具有统计学意义(P ＜0.000 1),且并不增加药物不良反应.结论:榄香烯乳联合顺铂胸腔灌注治疗恶性胸腔积液疗效优于单用顺铂,且不良反应发生率低.%Objective:To systematically evaluate the clinical efficacy and safety of elemene combined cis-platinum pleural perfusion for the treatment of malignant pleural effusion.Methods:" Elemene emulsion,cis-platinum,malignant pleural effusion,Meta-analysis" were the key words,and the following databases were retrieved by computer:Pubmed,CNKI,Wanfang data base,FMRS and so on.To collecte the radomized controlled trials about elemene combined cis-platinum pleural perfusion for the treatment of malignant pleural effusion (MPE),and RevMan 5.3 software was used for Meta-analysis.Results:Six RCTs were adopted,and included 463 patients of MPE.The method of radomized control was used by all these studies,the result was showed by the Meta-analysis.The effective rate of elemene emulsion combined cis-platinum pleural perfusion is better than the simple cis-platinum for the treatment of malignant pleural effusion,there was a significant difference (P ＜ 0.000 1),and did not increase the adverse of drug reactions.Conclusion:In the treatment of MPE,elemene emulsion combined cis-platinum pleural perfusion is better than the simple cis-platium,and had lower rate of adverse reactions.