Objective To investigate the effectiveness and safety of dinoprostone suppositories in promoting cervical ripening in the process of induction of labor in term pregnancy. Methods A total of 160 primiparous women with term and single pregnancy in line with the indicates of induced labor were divided into the observation group and the control group ,80 of each group. The lying-in women in the observation group were given dinoprostone suppositories in the posterior fornix of vagina while the control group were injected with oxytocin by vein. It is compared Bishop grading,labor condition,cesarean section as well as influence on the fetus and newborn before taking medicine and after 6h,12h,24h treatment. Results The Bishop score of the observation group is higher than that of the control group after 6 hours and 12 hours respectively as from taking medicine. The du-ration from taking medicine to labor and total stages of labor were shortened than those of the control group ,whose differences were statistically significant(P<0.05). After taking the medicine,66(82.5%) occurred regular uterine contraction to give a birth, 14 (17.5%) with irregular uterine contraction in the observation group while 26 (32.5%)occurred regular uterine contraction to give a birth,54(67.5%)with irregular uterine contraction in the control group(P<0.05). The overall response rate(82.5%) of pro-moting cervical ripening in the observation group was distinctly higher than that(32.5%)of the control group,whose difference was statistically significant(P<0.05). The cesarean section rate(17.5%) of the observation group was inferior to that of the control group (P<0.05). The incidence rate of adverse rate,body mass of the newborns and Apgar scores of the two groups were compared and showed no significant difference(P>0.05). Conclusion Dinoprostone suppositories is better for promoting cervical ripening and la-bor induction,being safe and effective,which has less adverse effects on newborns and mothers,being worthy to promotion in clinic.%目的：探讨欣普贝生（地诺前列酮栓）用于足月妊娠引产中促宫颈成熟的有效性和安全性。方法选取2010年10月至2013年10月收治的足月妊娠并具备引产指征的160例初产妇，分为观察组和对照组，各80例。观察组产妇采用在阴道后穹隆放置欣普贝生引产；对照组产妇采用静脉注射催产素引产。比较两组产妇用药前及用药6、12、24 h后的Bishop宫颈成熟度评分、临产情况、剖宫产率以及对胎儿和新生儿的影响。结果观察组产妇用药6、12 h后Bishop宫颈成熟度评分高于对照组，用药到临产时间、总产程较对照组明显缩短，差异均有统计学意义（P＜0.05）。观察组用药后66例（82.5%）出现规则宫缩而临产，14例（17.5%）有不规则宫缩；对照组26例（32.5%）出现规则宫缩而临产，54例（67.5%）有不规则宫缩，两组比较，差异有统计学意义（P＜0.05）。观察组促宫颈成熟总有效率（82.5%）明显高于对照组（32.5%），而剖宫产率（17.5%）低于对照组（67.5%），差异均有统计学意义（P＜0.05）。两组产妇不良反应发生率比较，差异无统计学意义（P>0.05）。两组新生儿出生体质量及Apgar评分比较，差异均无统计学意义（P＞0.05）。结论欣普贝生用于足月妊娠引产中促宫颈成熟效果较好，安全有效且对母婴的不良影响小，值得临床推广应用。
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