视黄醇结合蛋白4、超敏C反应蛋白水平与糖尿病足的关系

摘要

Objective:To investigate serum retinol binding protein 4 (RBP4) and hypersensitive C‐reactive protein (hsCRP) levels in patients of diabetic foot (DF) .Methods:Serum sample were taken from 72 patients with DF ,51 pa‐tients with T2DM and 35 normal controls .The basic clinical information were collected .RBP4 ,hsCRP and biochemical indicators were determined in all subjects .Results:The level of HbA1c ,UA ,Cr ,HOMA‐IR ,WBC ,serum RBP4 and hsCRP in DF group were significantly higher than those in DM group and the control group(P<0 .05) .UA ,Cr ,age , BMI ,HOMA‐IR ,WBC ,hsCRP were significantly correlated with serum RBP4 .The Logistic regression analysis showed that the hsCRP (r=0 .453 ,P<0 .01) ,HbA1c (r=0 .551 ,P<0 .01) ,RBP4 (r=0 .362 ,P<0 .01) is the independence related factors in patients of DF .Conclusion:Patients of DF have high levels of serum RBP4 and hsCRP ,which may be involved in the development of DF .%目的：探讨视黄醇结合蛋白4（RBP4）、超敏C反应蛋白（hsCRP）与糖尿病足（DF）的关系。方法：选取单纯2型糖尿病（T2DM ）患者51例（DM组），T2DM合并DF患者72例（DF组），门诊健康体检者35例（对照组），收集基本临床资料，检测RBP4、hsCRP、FBG、HbA1c、UA、Cr、HOMA‐IR、WBC等指标，并对结果进行统计分析。结果：DF组的HbA1c、UA、Cr、HOMA‐IR、WBC、血清 RBP4和 hsCRP水平均高于 DM 组和对照组，差异均有统计学意义（P＜0.05）。DF组相关性分析示UA、Cr、年龄、BMI、HOMA‐IR、WBC、hsCRP与血清RBP4呈正相关。Logistic回归分析结果表明hsCRP（r＝0．453，P＜0．01）、HbA1c（r＝0．551，P＜0．01）、RBP4（r＝0．362，P＜0．01）是DF发生的独立相关因素。结论：血清RBP4、hsCRP与DF的发生发展有一定联系，是DF的危险因素。