降钙素原在老年非ST段抬高性心肌梗死并SIRS患者诊治中的意义

摘要

Objective:To investigate the significance of procalcitonin in treatment for elderly non-STsegment elevation acute myocardial infarction with SIRS.Methods:100 cases of elderly patients with non-ST segment elevation acute myocardial infarction with SIRS were randomly divided into observation group and control group,50 cases each.The control group was treated by percutaneous coronary intervention (72h),and the use of antibiotics was determined according to the conventional inflammatory parameters and experience.The observation group was treated with different treatment options according to the level of detection of calcitonin.The use of antibiotics in the two groups,the average length of hospital stay and the incidence of adverse events were compared.Results:There was significant difference in antibiotics drug use rate and average length of hospital stay between 2 groups (P<0.05).The incidence of renal function deterioration cardiac ischemic event was lower in observation group than control group, one month after operation,The difference was statistically significant (P<0.05).Conclusion:Procalcitonin-guided treatmen tragedy combined with SIRS for elderly non-ST segment elevation acute myocardial infarction could optimize the timing of intervention to promote rational use of antibacterial to reduce the incidence of adverse events.%目的:探讨降钙素原在老年急性非ST段抬高性心肌梗死合并全身炎症反应综合征(SIRS)患者诊治中的临床意义.方法:将100例老年急性非ST段抬高性心肌梗死合并SIRS患者随机分为观察组和对照组,各50例.对照组行早期(72h)经皮冠状动脉介入治疗,并根据常规炎症指标以及经验决定抗生素的使用时机;观察组根据检测的降钙素原水平采用不同的治疗方案.对比两组抗生素使用情况、平均住院天数以及术后1个月不良终点事件发生的情况.结果:观察组出院后1个月内的再缺血事件、肾功能恶化率及总终点不良事件较对照组明显降低(P<0.05);观察组的抗生素使用率及平均住院天数较对照组明显降低(P<0.05).结论:在老年急性非ST段抬高性心肌梗死合并全身炎症反应综合征患者中检测降钙素原,可以据此优化介入治疗时机的选择,促进抗生素的合理应用,减少不良终点事件的发生.