Objective To study the ameliorative effect of phyllanthus emblica on hepatic injury and inflammation in rat non - alcoholic fatty liver disease ( NAFLD) model. Methods Twenty one healthy female SD rat were randomly divided into 3 groups. Control group was fed with regular chow. NAFLD group was fed with high -fat diet (chow supplemented with 10% oil and 2% cholesterol). Phyllanthus emblica co - treated group was fed with high - fat diet accompanied by daily I. P. Injection of 0. 06 ml/g extract of phyllanthus emblica. Eight weeks later, serum and liver samples from rats were subjected to measurements. Results After 8 - week high - fat diet feeding, serum levels of ALT and AST in NAFLD rats were significantly increased. Obvious inflammatory site and fat accumulation were observed in NAFLD rats with up - regulation of hepatic pro - inflammatory factors. Co - treatment of phyllanthus emblica effectively attenuated fatty liver pathological features. Conclusion Phyllanthus emblica can ameliorate hepatic injury and inflammation during NAFLD.%目的 探讨余甘子对大鼠非酒精性脂肪肝模型中肝损伤和炎症的抑制作用.方法 将健康雌性SD大鼠21只随机分为3组.对照组大鼠以普通饲料喂饲,非酒精性脂肪肝组大鼠喂以添加10％的猪油以及2％胆固醇的高脂饲料.余甘子处理组大鼠的饲料与非酒精性脂肪肝组大鼠相同,另外每日每只大鼠注射0.06ml/g的余甘子萃取物.8周后取大鼠血清和肝脏进行检测.结果 高脂饲料喂养8周后,非酒精性脂肪肝组大鼠血清中谷丙氨酸转氨酶(ALT)和天门冬氨酸转氨酶(AST)显著上升,肝脏组织切片中出现明显的炎症位点和脂肪累积,肝脏中炎症因子(TNF-α、IL-1β、COX-2)的表达量亦显著上升.加入余甘子处理的非酒精性脂肪肝大鼠以上指标均有明显改善.结论 余甘子可改善非酒精性脂肪肝形成过程中肝脏的损伤和炎症的发生.
展开▼
