目的 探索深海鱼皮胶原蛋白寡肽(简称鱼皮寡肽)在肺癌患者化疗期间增效减毒的作用.方法 选择住院非小细胞肺癌患者60例,随机均分为干预组和对照组,每组各30例.干预组和对照组均接受TP化疗方案和其他常规治疗与护理.干预组在此基础上于化疗第1天开始加服用鱼皮寡肽.于化疗前后评价两组化疗骨髓抑制情况、消化道不良反应以及体力状况Karnofsky评分.结果 干预组化疗后白细胞总体下降率为60.00％,对照组为83.33％；血红蛋白下降率干预组为30％、对照组为60％；干预组均低于对照组,两组比较有统计学差异(P＜0.05)；消化道不良反应两组比较无统计学差异；Karnofsky评分化疗后干预组得分高于对照组,两组比较有统计学差异(P＜0.05).结论 鱼皮胶原蛋白寡肽能有效改善肺癌患者化疗期间骨髓抑制情况,提高患者生活质量,有很高的营养价值.%Objective To explore the effect of fishskin collagen - peptide of decreasing side effects during the chemotherapy in patients with non - small cell lung cancer( NSCLC). Methods Totally 60 patients of NSCLC were recruited and randomly divided into in-tervention group and control group. Patients in the two groups received the chemotherapy (TP regimen) and conventional treatment and care. The patients of intervention group took the fishskin collagen peptide since the first day of chemotherapy oraly. The hematological tox-icities and side effects on gastro - intestine and karnofsky score of the patients of the two groups were evaluated before and after chemotherapy. Results After chemotherapy, the total decline rate of leukocyte in the intervention group was 60% , in the control group was 83. 33% ; the rate of hemoglobin in the intervention group was 30% , in the control group was 60% . It was lower in the intervention group than that in the control group. There was significant statistical difference between the two groups. There was no significant statistical difference in the side effect of gastro - intestine between the two groups. The score of Karnofsky in the intervention group was better than that in the control group,and there was significant statistical difference. Conclusion The fishskin collagen - peptide can decrease the hematological toxicities and improve the quality of life in the patients with NSCLC. The collagen - peptide has good nutritional value.
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