1型糖尿病儿童晚期糖基化终末产物、血清抗苗勒管激素和抑制素B对儿童生殖器官发育影响的研究

摘要

Objective To investigate the effect of Children with type 1 diabetes mellitus on reproductive organ maturation.Methods 80 cases of 6-10 years old patients with type 1 diabetes Tanner stages Ⅰ were enrolled,including 41 girls and 39 boys;control group 85 cases,including 40 girls and 45 boys.We detected serum AGEs,AMH,INHB,four steroid sex hormones and HbA1 c levels respectively.Results Compared with the control group,girls with type 1 diabetes had a significant increase of serum AGEs,AMH,INHB and HbA1c level(P ＜ 0.05).Four steroid sex hormones had no statistically significant differences between girls with type 1 diabetes and control group(P ＞ 0.05).Compared with the control group,boys with type 1 diabetes have a significant increase of serum AGEs,AMH,HbA1c level and decrease of INHB(P ＜ 0.05).Four steroid sex hormones had no statistically significant differences between boys with type 1 diabetes and control group(P ＞ 0.05).Conclusion Children with type 1 diabetes mellitus has a negative impact on reprodu-tive organ maturation.%目的 研究1型糖尿病(type 1 diabetes mellitus,T1DM)对儿童生殖器官发育的影响.方法 选取6～10岁TannerⅠ期T1DM患儿80例,其中女性患儿41例,男性患儿39例;健康对照组85例,其中女性患儿40例,男性患儿45例.对所有入组儿童均采集外周血检测血清晚期糖基化终末产物(advanced glycosylation end products,AGEs)、血清抗苗勒管激素(anti miillerian hormone,AMH)、血清抑制素B(inhibin B,INHB)、性激素4项和糖化血红蛋白A1 c(glycosylated hemoglobin A1 c,HbA1c)水平,分别比较上述指标在不同性别儿童T1DM组与健康对照组之间的差异.结果 女性患儿T1DM组血清AGEs、AMH、INHB、HbA1c水平均较女性患儿健康对照组明显升高,差异有统计学意义(P＜0.05);女性患儿T1DM组血清性激素4项水平与女性患儿健康对照组比较,差异均无统计学意义(P＞0.05);男性患儿T1DM组血清AGEs、AMH、HbA1c水平均较男性患儿健康对照组明显升高,差异有统计学意义(P＜0.05);男性患儿T1 DM组血清INHB水平较男性患儿健康对照组则明显降低,差异有统计学意义(P＜0.05);男性患儿T1DM组血清性激素4项水平与男性患儿健康对照组比较,差异均无统计学意义(P＞0.05).结论 T1DM可能对儿童生殖器官发育成熟造成一定程度影响.