目的：探讨雌激素受体（estrogen receptor， ER）、孕激素受体（progesterone receptor， PR）、原癌基因（CerbB-2）表达水平与乳腺浸润性导管癌（ invasive breast cancers ， IDC）超声乳腺影像报告和数据系统分级（ breast imaging reporting and data system， BI-RADS）的关系。方法对2010年9月～2014年9月医院收治的120例IDC患者行超声检查并进行BI-RADS分级，采用免疫组化法检测患者ER、PR、CerbB-2阳性表达情况，分析BI-RADS分级与ER、PR、CerbB-2阳性表达的关系。结果肿块边缘有毛刺征者ER、PR表达阳性率显著高于边缘无毛刺征者（ P ＜0．05）；肿块内部钙化者CerbB-2表达阳性率显著高于无钙化者（ P ＜0．05）；肿块内血流0～Ⅰ级者ER、PR、CerbB-2表达阳性率显著高于Ⅱ～Ⅲ级者（ P ＜0．05）；肿块大小、后方回声有无衰减、UE评分与ER、PR、CerbB-2表达阳性率无明显相关性（ P ＞0．05）。 ER、PR、CerbB-2表达阳性的IDC患者BI-RADS分级均显著高于表达阴性者（ P ＜0．05）。结论 IDC患者超声征象能够在一定程度上预测ER、PR、CerbB-2表达的水平，从而为IDC的治疗、预后评估提供参考。%Objective To explore the relationship between the estrogen receptor , progesterone receptor and CerbB-2 expres-sion levels and breast imaging reporting and data system in invasive breast cancer patients .Methods 120 patients with invasive breast cancers selected from september 2014 to september 2010 underwent ultrasonic examination and BI-RADS classification. CerbB-2, PR and ER positive expression were detected by immunohistochemistry method .We analyzed relationship of BI-RADS grading and ER ,PR and CerbB-2 positive expression .Results Tumor margin spiculation in ER and PR positive expression rate was significantly higher than the edge without spiculation persons ( P <0.05);internal with calcification CerbB-2 expression pos-itive rate was significantly higher than that of non calcified persons ( P <0.05);flow stage 0~ⅠER, PR, CerbB-2 expression positive rate had significantly higher than that of II ~III stage ( P <0.05).ER, PR, CerbB-2 positive expression rate with no significant correlation between tumor size , rear echo with or without attenuation , UE score ( P >0.05).The positive expression of ER, PR, CerbB-2 in IDC patients with BI-RADS stage was significantly higher than those in negative expression ( P <0.05). Conclusion IDC patients ultrasonic sign can predict the level of ER , PR and CerbB-2, so as to provide a reference for the treat-ment and prognosis of IDC .
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