Objective To investigate and compare the serum levels of lipid profiles in rheumatoid arthritis (RA) patients with active and inactive phase, explore the relationship between dyslipidemia, inflammation and car-diovascular risk in RA patients, then provide a theoretical basis for early clinical intervention for the dyslipid-emia and cardiovascular complications in patients with RA. Methods 100 newly diagnosed RA patients with active and inactive phase, 50 each group were involved in the present study:Levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), apolipoprotein A1 (Apo-Al), apolipoprotein B (Apo-B), lipoprotein a (Lpa), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antibodies against cyclic citrullinated peptide (ACCP) were assayed, as well as the disease ac-tivity score-28 (DAS28) was measured, atherogenic index of plasma(AIP)was calculated by the results of tri-glyceride (TG) and high-density lipoprotein (HDL-C). Results Compared to the patients with inactive RA,levels of Lpa, AIP were higher and Apo-Al was lower in patients with active RA (P<0.01 or P<0.05);The Pearson analysis of RA patients with active phase showed that ESR, CRP, DAS28 were positively correlated with Lpa, AIP, ACCP were positively correlated with AIP (all P<0.05). Conclusion There is a correlation be-tween RA and cardiovascular risk in active stage, and ACCP plays a certain role in the prediction of cardiovas-cular risk .%目的：通过测定及比较类风湿关节炎（RA）活动期与非活动期患者的血脂水平，探讨RA患者血脂异常的特点及炎症对血脂的影响，为临床早期干预RA患者血脂紊乱及心血管并发症提供理论依据。方法研究对象共100例，其中活动期与非活动期患者各50例。测定各组总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、载脂蛋白A1（Apo-Al）、载脂蛋白B （Apo-B）、脂蛋白a （Lpa）、红细胞沉降率（ESR）、C反应蛋白（CRP）、抗环瓜氨酸抗体（ACCP），计算血浆致动脉粥样硬化指数（AIP），应用疾病活动性评分（DAS28）评定患者的疾病活动性。结果活动期RA与非活动期相比， Lpa、AIP高于非活动期， Apo-Al低于非活动期（P<0.01或P<0.05），差异有统计学意义；经Pearson相关分析显示：活动期RA患者ESR、CRP、DAS28分别与Lpa及AIP呈正相关， ACCP与AIP呈正相关，且差异有统计学意义（P<0.05）。结论活动期RA与心血管风险存在一定的相关性，ACCP具有预测心血管风险的意义。
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