主动脉夹层动物模型构建方法研究现状

摘要

Aortic dissection is a dangerous and critical disease with extremely high mortality and disability rate.In clinical practice,aortic dissection should be highly suspected when patients developed dying-like severe chest and back pain.CT and MRI have been the reliable tools for diagnosing aortic dissection.In recent years,endovascular therapy has become the preferred treatment for Stanford type B aortic dissection,and some patients with Stanford type A dissection who cannot receive open surgery may also be treated with endovascular therapy.In order to improve endovascular treatment,to develop new instruments and to study the pathogenesis of aortic dissection,the preparation of stable and reliable animal models is very necessary.This paper aims to make a brief review about the research status concerning the preparation of animal models of aortic dissection.%主动脉夹层是一种致死致残率极高的危急疾病,患者出现濒死样剧烈胸背部疼痛应怀疑此病可能,CT或MRI是诊断该病的可靠方法.近年腔内治疗已成为Stanford B型主动脉夹层首选治疗方法,部分无法开放手术治疗的Stanford A型夹层患者也可采用腔内治疗方法.为了改进腔内治疗方法、开发新器械、研究主动脉夹层发病机制,需要构建出稳定的动物模型.该文就主动脉夹层动物模型构建研究现状作一综述.